Supervised by:Dr.Eftekhar

Peresented by:Mohsen Koolivand

MSC Clinical of Biochemistry

Muscle Diseases

به نام خدا

OutlineIntroduction

Marker of muscle damage

Muscle dystrophies

Metabolic myopathies

Other myopathies

Introduction

Marker of muscle damage

CK

Tree forms M-B-MM

CK-MB : Use of management of chest pain

The highest activities in : necrosis , Duchenne

Serial plasma CK : for myopathic and response to treatment

Normal plasma CK

Other enzymes for marker

Aldolase , lactate dehydrogenase , myoglobin

In severe muscle damage, myoglobinuria can occur and cause a

brown colouration of the urine. Myoglobin can precipitate out in

the renal tubules and cause an obstructive nephropathy: the renal

failure associated with crush injuries is in part due to this.

Muscle dystrophiesMuscular dystrophy (MD) is a broad term that describes a genetic (inherited)

disorder of the muscles. Muscular dystrophy causes the muscles in the body to

become very weak.

Metabolic myopathies

Neuromuscular disorders in which the primary

symptom is muscle weakness due to dysfunction of

muscle fiber

Inflammatory Myopathies Polymyositis Dermatomyositis Inclusion body myositis Viral

Muscular dystrophies Duchenne muscular Limb-girdle Congenital Fasioscapulohumeral Oculopharyngeal Emery – Dreifuss Distal (Welander)

Myotonic Syndromes Myotonic dystrophy Inherited Schwarz-Jampel Drug-induced

Congenital myopathies Central core disease Nemaline myopathy Myotubular Fiber-type disproportion

Metabolic myopathies Glycogenoses Mitochondrial Periodic paralysis

Endocrine myopathies Thyroid Parathyroid Adrenal/steroid Pituitary

Drug-induced/toxic

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Other myopathies

Myotonia

Myasthenia gravis

Lambert–Eaton myasthenic syndrome

God is looking for clean hands and a pure heart