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Insulin Pdx4. A. WT. KO. Figure S1. A. Lactate levels (mice). B. NADPH levels (livers). P < 0.03. P < 0.009. Figure S2. Expression levels of glycolytic genes in KO MEFs. A. Expression levels of TCA cycle genes in KO MEFs. B. Figure S3. Expression levels of Pentose Phosphate - PowerPoint PPT Presentation
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WT KO
InsulinPdx4
Figure S1
A
Lactate levels (mice)A
P< 0.009
NADPH levels (livers)B
P< 0.03
Figure S2
Expression levels of glycolytic genes in KO MEFsA
Expression levels of TCA cycle genes in KO MEFsB
Figure S3
Expression levels of Pentose Phosphate Pathway genes (MEFs)C Expression levels of Gluconeogenesis genes (MEFs)D
Expression levels of Gluconeogenesis genes (livers)E
Figure S3
A HIF1α target genes expression (MCF7) HIF1α target genes expression (MCF7)B
C
P< 0.001
P< 0.09
P< 0.001
P< 0.01
HRE-Luciferase Assay HIF1α mRNA levels in skeletal musclesD
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**
**
**
* * *
Figure S4
A NBDG-glucose uptake
CB HIF1α target genes expression in KO treated miceHIF1α target genes expression in WT treated mice
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Figure S5
Cont
rol
GST
WW
1
GST
WW
2
GST
WW
1+2
GST
SD
R
Cont
rol
GST
WW
1
GST
WW
2
GST
WW
1+2
GST
SD
R
MG132 HypoxiaInput
Cont
rol
GST
WW
1
GST
WW
2
GST
WW
1+2
GST
SD
R
Cont
rol
GST
WW
1
GST
WW
2
GST
WW
1+2
GST
SD
R
MG132 HypoxiaPull down
A
HIFα
GST
HIFα
GST
HSP90
WWOX interacts physically with HIF1α via its first WW domain
HIFα-OH
LAMIN
HIFα
WWOX
Anti-
ww
ox
Anti-
HIF
α
Anti-
IgG
Lysi
s
Anti-
ww
ox
Anti-
HIF
α
Anti-
IgG
Lysi
s
Normoxia (+MG 132)
Hypoxia
IP:
Endogenous WWOX physically interacts with
endogenous HIF1α
B
Figure S6
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