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Medical science and education of uralfounded in 1999Practical Journal2 (66), June. Vol. 12, 2011issued four times a year.

Editorial staff:Medvedeva i. V., Editor in Chief, corresponding member of Russian Academy of Medical Sciences, Ph. D., prof. (Tyumen)

Kashuba E. a., Deputy Editors in Chief, Ph. D., prof. (Tyumen)

orlov s. a., Science in Chief, M. D.salov r. M., Project director Editorial board:Zaharov Y. M., academician of the Russian Academy of Medical Sciences, Ph. D., prof. (Moscow) Martynov a. i. academician of the Russian Academy of Medical Sciences, Ph. D., prof. (Moscow)buganov a. a., corresponding member of the of Russian Academy of Medical Sciences, Ph. D., prof. (Nadym)Kuxarchuk V. V., corresponding member of the of Russian Academy of Medical Sciences, Ph. D., prof. (Moscow)arutyunov G. P., Ph. D., prof. (Moscow)Zhmurov V. a., Ph. D., prof. (Tyumen)Konovalova N. a., Ph. D., prof. (Tyumen)Mashkin a. M., Ph. D., prof. (Tyumen)Polyakova V. a., Ph. D., prof. (Tyumen)stepanova t. f., Ph. D., prof. (Tyumen)shalaev s. V., Ph. D., prof. (Tyumen)brynza N. s., Ph. D. (Tyumen)Kudryakov a. Y., (Tyumen)

PublishEr GrouP:Zachryapina T. V., Kuchasheva S.V.

ProMotErs:

The Tyumen department of the Southern-Urals scientific centre RAMS

Tyumen State Medical Academy

The Journal is in the List of the leading scientific journals and publications recommended by Higher Assessment Board (VAK), which are to publish the results of Ph. D. theses.

internet: www.tyumsma.ru; www.elibrary.ru

address:54, Odesskay St., Tyumen, 625023, Russia. Tel. (3452) 20-07-07 E-mail: redotdel@tyumsma.ru

contents

CLINICAL RESEARCHES . . . . . . . . . . . . . . . . . . . . . .9Akinina S. A.BASELINE AND POST-PROCEDURAL TROPONIN T ELEVATIONS FOR PATIENTS WITH CORONARY ARTERY DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTIONS . . . . . . . . . . . . . .9

Antonov M. V., Sabirov A. Kh., Mystaev O.Z.TARGETED THERAPY COLORECTAL CANCER . . . . . . . . . . . . . . .13

Vazhenin A. V., Shanazarov N. A., Nalgieva F. H.EFFICACY OF ENDOVASkULYARNOY HImIOmBOLIzACII IN A COmBINED TREATmENT OF CERVICAL CANCER, COmPLICATED BLEEDING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17

Gamzatova Z. A., Petrov I. M, Vasilieva I. V.ESTImATION REmOTE RESULT PREVENTIVE CONSULTANCY PATIENT WITH OVERWEIGHT AND ABDOmINAL OBESITY . . .21

Zuban O. N., Chotchaev R. ., Popov I. B.THE ROLE OF THE LENGTH OF ILEAL LOOP USING FOR CYSTOPLASTY IN mETABOLIC AND URODYNAmIC DISORDERS DEVELOPmENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25

Ibragimova E. A., Klyasheva J. M., Klyashev S. M., Kalinina V. L., Triodina O. V.THE FREqUENCY AND THE NATURE OF CARDIAC RHYTHm AND CARDIAC CONDUCTION DISTURBANCE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE OBSTRUCTIVE SLEEP APNEA SYNDROmE BY 24-mONITORING OF ECG . . . . .28

Kolinko L. P., Nazarenko S. V., Gazizova D. N., Petrova Y. A., Medvedeva I. V.THE CHARACTERISTIC NUTRITION STATUS AT THE PREGNANT AND LACTATION WOmEN LIVING IN CONDITIONS OF THE NORTH . . . . . . . . . . . . . . . . . . . . . . . . .32

Nerodo G. A., Kalabanova E. A., Levchenko N. E.THE ANALYSIS OF TERmS OF mETASTASES OCCURRENCE AND SURVIVAL OF PATIENTS WITH mETASTATIC CERVICAL CANCER DEPENDING ON VARIOUS FACTORS . . . . . . . . . . . . . .36

Slepov M. N., Pelevin A. R., Gooz G. G., Tchernak A. Y., Petrov I. M.POSTPRANDIAL LEVEL OF INFLAmmATION mARkERS AT PATIENTS WITH PREDIABETES AGAINST USE OF VARIOUS PROGRAmS OF CORRECTION . . . . . . . . . . . . . . . .39

Sagitova E. R., Bagirova G. G.CARDIOVASCULAR mANIFESTATIONS OF ATHEROSCLEROSIS IN PATIENTS WITH RHEUmATOID ARTHRITIS . . . . . . . . . . . . . .43

Slepov M. N., Pelevin A. R., Gooz G. G., Tchernak A. Y., Medvedeva I. V., Shalomov I. F.CORRECTION mETABOLIC PARAmETERS AND ENDOTHELIUm FUNCTION DYNAmIC IN OBESE PATIENTS, LIVING OF THE NORTH . . . . . . . . . . . . . . .47

Ushakova S. A., Kulichenko M. P., Petrushin A.D., Zhuravleva T. D.FEATURES LIPID, CARBOHYDRATE AND PURINE mETABOLISm IN ADOLESCENTS WITH ARTERIAL HYPERTENSION AND ABDOmINAL OBESITY . . . . . . . . . . . . . .51

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Charyshkin A. L., Vasilev M. N.RESULTS HERNIA PLASTIC THE POSTOPERATIVE mEDIAN ventral THE HERNIAS . . . . . . . . . . . . . . . 55

Shavrin A. P.THE VALUE OF INFECTIOUS AND NON-INFECTIOUS FACTORS IN THE PROCESSOF ATHEROSCLEROSIS DEVELOPmENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59

Shmyrev V. I., Sokolova L. P.FEATURES IN THE mETABOLISm OF BRAIN mILD TO mODERATE (DODEmENTNYH) COGNITIVE DISORDERS OF VARIOUS ORIGINS . . . . . . . . . . . . . . 64

ORIGINAL RESEARCHES . . . . . . . . . . . . . . 69Amaranthov D. G., Balandina I. A., Nagaev A. S.TACTICS OF THE SURGICAL TREATmENT LImITED SHARP FESTERING PLEURISY . . . . . . . . . . . . . . . . . . . 69

Kalenova L. F., Novikova M. A., Markelova P. P., Besedin I. M., Ivanova N. V., Ivanova E. V.EFFECT OF LOCAL EFFECTS OF TEmPERATURE FACTOR ON REPAIR SkIN WOUNDS IN THE EXPERImENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72

Koynosov P. G., Nikolaeva O. P., Orlov S. A., Prokopiev A. N., Koynosov A. P., Hvesko A. S., Zavalko Y. V.STRUCTURAL AND FUNCTIONAL VARIABILITY OF THE CONSTITUTION OF CERTAIN CHILDREN . . . 76

Kolpakov V. V., Bespalova T. V., Tomilova E. A., Larkina N. J., Mamchits E. V., Storck T. E., Kopytov A. A., Yuffa N. P.PHYSIOLOGICAL NORm AND PRENOSOLOGICAL DIAGNOSIS OF DIFFERENT TYPES OF PATHOLOGY . . 80

Nekrasova L. V., Sudyukov O. A., Torsunova Y. P., Melnikov I. I.ANATOmOmETRIC CHARACTERISTICS OF A mEDIAN NERVE IN VARIOUS TERmS AFTER ITS COmPRESSION IN EXPERImENT . . . . . . . 86

Nerodo G. A, Nepomnyaschaya E. M., Novikova I. A., Shishkina O. G.DNA CYTOmETRIC ANALYSIS OF CELL CYCLE PARAmETERS OF TUmORS OF THE CORPUS UTERI IN YOUNG WOmEN . . . . . . . . . . . . . . . . . . . . . 89

Nurgaleeva E. A., Enikeev D. A., Laptev O. V., Nagaeva L. V.THE ROLE OF STRUCTURAL AND mETABOLIC ABNORmALITIES OF THE LIVER OF RATS IN THE mECHANISmS OF FORmATION OF E ENDOTOXICOS AFTER UNDERGOING LETHAL HEmORRHAGE . . . . 92

Samoilov M. , Tkalenko I. ., sheev V. V.INFLUENCE OF NIACIN AND ASPIRIN ON FREqUENCY OF THE SURVIVAL OF ANImALS AT EkzOGENNOJ THROmBINNAEmIA . . . . . . . . . . . . . . . . . . . . . . . . . . . 95

Timokhina T. Ch., Gubin D. G.CIRCADIAN AND ULTRADIAN RHYTHmICITY FOUND IN SOmE VARIABLES OF HOSPITAL AND mUSEUm STRAINS OF S . AUREUS, E . COLI, P . AERUGINOSA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98

Trifonova E. B.FEATURES OF BONE REmODELING AFTER CLOSED DISTRACTION OSTEOSYNTHESIS UNDER REDUCED BONE mINERAL DENSITY . . . . . . . . . . . . . . . . . . . . . 101

Shtork T. E., Bespalova T. V.PHYSIOLOGICAL BASES OF PRENOzOLOGICAL DIAGNOSTICS OF VARIOUS FORmS OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105

ExCHANGE Of ExpERIENCE . . . . . . . . . 109Bayburina G. G., Mustafina G. H.THE CLINICAL AND ImmUNOLOGICAL ASSOCIATIONS STUDIED AT DIABETES mELLITUS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109

Balandina I. A., Amaranthov D. G., Kosareva P. V., Nagaev A. S.THE DIAGNOSTICS TO STAGE FESTERING PLEURISY . . . . . . . . . . . . . . . . . . . . . . . . 112

Bondarevsky I. Ya.EEXPERImENTAL AND CLINICAL EVIDENCE EFFECTIVE LIVER RESECTION BY DIOD LASER USED . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115

Bychenko S. M., Kicherova O. A.THE CONNECTION OF mULTIPLE SCLEROSIS DEVELOPmENT WITH mEmDRANO-DESTABILIzE PROCESSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118

Bychenko S. M., Kicherova O. A., Rejhert L. I.mECHANISmS ACTIONS ACETATE AT A mULTIPLE SCLEROSIS . . . . . . . . . . . . . . . . . . . . 121

Volokh E. V., Chernisheva T. V., Richkova O. A., Kozhevnikova L. A.INFLUENCE OF CHRONIC VIRAL HEPATITIS ON THE STATE OF VEGETATIVE NERVOUS SYSTEm AmONG CHILDREN . . . . . . . . . . . . . . . . . . . 125

Diachkov A. N., Soldatov Yu. P., Stolbikov S. A., Zverev E. S.COmPARATIVE STUDY OF FAILUP^S AND COmPLICATIONS IN TREATmENT OF PATIENTS WITH CLOSED TIBIAL FRACTURES WITH CONSERVATIVE AND SURGICAL TECHNFIqUES AT mUNICIPAL HOSPITAL AND mEDICAL UNIT . . . . . . . . . . . . . . . . . . . . . . . . . . 127

Zyryanov S. Ya., Nalgyev A. H., Zyryanov S. S.SURGICAL TREATmENT OF FLATFOOT IN EXTENSION OF FIRST mETATARSAL BONE . . . . 131

Ilkanich A. J., Lobanov D. S.TO A qUESTION ABOUT THE TREATmENT OF PATIENTS WITH POLYPS OF THE COLON . . . . . 133

Kamilov F. Kh., Ibragimov B. A., Altynova A. F, Davletova E. A, Mirsayeva G. Kh.INTENSITY OF LIPOPEROXIDATION PROCESSES IN PERSONS CONVALESCING FROm HEmORRHAGIC FEVER WITH RENAL SYNDROmE . . . . . . . . . . . . . . . 136

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Kapuler O. M., Kamilov F. Kh., Kungurov N. V.THE RELATIONSHIP OF CERTAIN CLINICAL CHARACTERISTICS AND ImmUNOLOGICAL PARAmETERS IN PATIENTS WITH PSORIASIS . . . . 139

Maltsev S. A.CLINICAL ASPECTS OF PREVENTION OF STENOSES OF A TRACHEA AND A THROAT WITH USE STRENGTHENED BY ARGON COAGULATION . . . . . . . 142

Pavlova V. I., Frolova O. I.THE CHARACTERISTIC OF THE ENDOGENOUS INTOXICATION SYNDROmE ON THE SURGERY PHASE OF BREAST CANCER . . . . . . . . . . . . . . . . . . . 145

Yakubova E. G., Makarova O. B., Suplotova L. A., Kukarskaya I. I.THE PREVALENCE OF IODINE DEFICIENCY IN A POPULATION OF PREGNANT WOmEN AND ITS EFFECT ON PERINATAL OUTCOmES . . . . . . . . . . . . 148

Yarkova V. G., Zhmurov V. A., Dubskikh I. A., Shumasova A. S., Bogdanov A. S., Zadorin T. G., Skomorohova V. N.CENTRAL HEmODYNAmICS IN DRIVERS AND THEIR ASSISTANTS, PATIENTS WITH ESSENTIAL HYPERTENSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151

GuIdELINES fOR tHE pRACtItIONER . . 154Anichenko P. N.NEW APPROACHES TO AN EXPERT ESTImATION OF mEDICAL AIDS qUALITY PLEDGE OF INCREASE OF EFFICIENCY OF mEDICAL-DIAGNOSTIC PROCESSES CLINICAL HOSPITAL . . . . . . . . . . . . . . . 154

Arybzhanov D. T.THE COmBINED TREATmENT OF THE STOmACH CANCER WITH APPLICATION OF ENDOVASCULARY mETHODS OF INFLUENCE . . . . . . . . . . . . . . . . . . . . 159

Bakhtin V. A., Yanchenko V. A., Serebrennikova E. N.LONG-TERm RESULTS OF SURGICAL TREATmENT OF COmPLICATED PANCRETIC PSEUDOCYSTS USING NONCONTACT ARGON PLASmA COAGULATION . . 161

Borisenok A. I., Knish O. I.STUDY THE FEATURES OF THE mEDICAL AND mEDICINAL AID TO CHILDREN AND ADOLESCENTS IN EDUCATIONAL INSTITUTIONS OF THE CITY OF TYUmEN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163

Vasiliev A. P., Streltsova N. N., Sekisova M. A.ASPECTS OF CURRENT DEVELOPmENT OF CARDIOVASCULAR PHARmACOLOGY . . . . . . . . 167

Volkova J. L., Strelin S. A., Makhnev A. V.AN EXPERImENTAL STUDY OF HEmOSTATIC SPONGE OF RECONSTITUTED OkSIGENIzIROVANNOY CELLULOSE TO STOP BLEEDING FROm THE WOUNDS OF THE LIVER . . 171

Zakharova N. A., Duffy S. W., Mackay J., Kotlyarov Y. V.THE EVALUATION OF THE BREAST CANCER EPIDEmIOLOGY IN THE kHANTY-mANSIYSkY AUTONOmOUS OkRUG UGRA DURING 2002-2010 YEARS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173

Zotov P. B., Umansky M. S., Koutsenko N. I., Kuznetsov P. V.SUICIDAL REGISTER THE FIRST EXPERIENCE OF THE SYSTEm OF ACCOUNTING SUICIDE . . . . . . 175

Ivanov V. V., Svazyan V. V., Lebedev K. A., Akselrov M. A., Bel'kovich S. V., Rushanyan R. G.PECULIARITIES OF THE DIAGNOSIS OBSTRUCTIVE UROPATHY IN INFANTS . . . . . . . . . . . . . . . . . . . . . . . 177

Ignatov S. V., Ignatova N. V., Zuevskaya T. V.EFFICIENCY OF DRY BICARBONATE BATHS AT THE SANATORIUm STAGE OF POSTINFARCTION REHABILITATION . . . . . . . . . 179

Iluyshenko N. A. Ragozina O. V.DEPENDENCE OF THE DYNAmICS OF PHYSICAL DEVELOPmENT OF CHILDREN FIRST TWO YEARS OF LIFE LIVING IN UGRA, THE GESTATIONAL mATURITY AND LEVEL OF ADAPTATION TO POSTNATAL ONTOGENESIS . . . . . . . . . . . . . . . . . . . 182

Koynosov A.P.INFLUENCE OF mATURITY SOmATOTYPOLOGICAL BODY WOmEN IN THE mIDDLE OB CLINICAL ILLNESS SkIN . . . . . . . . . . . . . . . . . . . . . . . 186

Kryukova A. Ya., Kuramshina O. A., Kofanova Yu. A.A RATIONAL CONVERSATION WITH PATIENTS WITH PEPTIC ULCER AN EFFECTIVE mETHOD OF PSYCHOLOGICAL PREPARATION FOR THE FASTING-DIET THERAPY . . . . . . . . . . . . . . . . . . 189

Kudrjakov A. J.mEDIkO-DEmOGRAPHIC SITUATION IN THE TYUmEN REGION, TENDENCIES OF CHANGES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191

Novikova T. S., Medvedev I. V., Brynza N. S., Velizhanin O. S., Utkin K. V.BIOCHEmICAL COmPOSITION OF BLOOD AND BILE IN PATIENTS OF CHOLELITHIASIS ON THE BACkGROUND OPISTHORCHIASIS . . . . . . 194

Orlov, A. S., Kostarev S. I., Sannikov A. G.ANALYSIS OF THE NEUROSURGICAL DEPARTmENT OF A mULTIDISCIPLINARY CLINIC BY mEANS OF AN AUTOmATED INFORmATION SYSTEm . . . . . 196

Podgayeva V. A., Golubev D. N., Chernyaev I. A., ShulevP. L. EPIDEmIOLOGICAL SITUATION ON TUBERCULOSIS INCIDENCE IN POPULATION OF URALS AND ImPACT OF SOCIAL AND ECONOmICAL FACTORS ON ITS FORmATION . . . . 200

Pulatov A. R., Markov I. V., Kozhevnikov M. A.PROGNOSIS IN LEGG-CALVE-PERTHES DISEASE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204

Malishevskaya O. I., Knish O. I., Dolgova I. G., Malishevskaya T. N.EVALUATION OF qUALITY OF LIFE OF GLAUCOmA PATIENTS USING VARIOUS OPTIONS HYPOTENSIVE THERAPY . . . . . . . . . . . . . . . . . . . . . . 207

8 2/2011

contents

Smorkalova E. V., Nikulicheva V. I., Aznabaeva L. F., Safuanova G. Sh., Chepurnaja A. N.STAGE-BY-STAGE REHABILITATION OF ANEmIAS SICk PATIENTS IN POLYCLINIC CONDITIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210

Trapeznikov K. M., Petrov V. G., Malinin D. I., Glinskay A. V.THE EXPERIENCE OF ENDOVIDEOSURGICAL TECHNOLOLOGY AT DIAGNOSTICS AND TREATmENT THE OPEN INJURES OF ABDOmINAL CAVITY . . . . . . . . . . . . . . . . . . . . . . 213

Shevchuk V. V.STRUCTURAL CHANGES IN THYROID AND THEIR DIAGNOSTIC VALUE OF U BOYS IN IODINE DEFICIENCY REGIONS . . . . . . . . . . . . . . . . . . . . . . . . 216

Epelman B. V., Sedavnyh I. S.THE EXPERIENCE OF REHABILITATION CARE FOR THE POPULATION OF LARGE CITY . . . . . . . . . . 218

Yusupov A. M., Kulakeev O. K., Arybzhanov D. T.ONkOEPIDEmIOLOGY INDICATORS OF THE ESOPHAGUS CANCER IN SOUTH kAzAkHSTAN . . 221

Duffy S. W., Zakharova N. A.THE BREAST CANCER SCREENING PROGRAm IN kHANTY-mANSIYSkY AUTONOmOUS OkRUG UGRA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223

REvIEwS . . . . . . . . . . . . . . . . . . . . . . . . . 225Ena I. I., Shanazarov N. A., Gladkov O. A.mODERN STRATEGY OF SURGICAL TREATmENT STOmACH CANCER . . . . . . . . . . . . . . . . . . . . . . . . . . 225

Karpova I. A.IS THE EFFECT OF ESTROGEN AND PROGESTOGEN ON HEmOSTASIS WITH THEIR EFFECT ON LIPIDPEROXIDATION? . . . . . . . . . . . . . . . . . . . . . 232

Fomina I. V., Polyakowa V. A.mODERN mETHODS RESEARCH VASCULAR THROmBOCYTIC BLOOD STASIS (REVIEW) . . . . . . 235

Hovari L. F., Shanazarov N. A., Shunko E. L.COmPARATIVE ANALYSIS OF INFORmATIVENESS OF mODERN RADIODIAGNOSTIC mETHODS kIDNEY CANCER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238

9 2/2011

. . - , . -

. - 3, 5 .

: , - , .

: . (3467) 39-01-67 . E-mail: nordcardiolog@mail .ru

akinina s. a.

BASELINE AND POST-PROCEDURAL TROPONIN T ELEVATIONS FOR PATIENTS WITH CORONARY ARTERY DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTIONS

Periprocedural elevation of TnT level, compared with patients with abnormal pre-PCI TnT level, correlates to higher rate of non-fatal mIs only during in-hospital period . A trend of diminished survival associated with elevated pre-PCI TnT level for short-term and long-term follow-up periods in correlation with TnT elevation in 3x, 5x and more the upper reference level is established .

Key words: percutaneous coronary intervention, preprocedural troponin T elevation, postprocedural troponin T elevation.

. () - . , , - . - , q- , () . , 20 [4] . - [1, 11] . , , - (k-mB), -

[4, 8], - . - - - . [2, 7] . -, , , - . - [6, 9] . , , , , , .

10 2/2011

. () - () () .

. 153 , 108 (70,6%) () . () - . (- ) . . - . . - 8 24 . Cardiac reader (- 0,03 /, 0,1-2,0 /) (Roche Diagnostics) - . - Beckman Coulter Synchron X . - - 0 25 / . - 20% . - ESC/ACC/AHA/WHF 2007 ., [10] . //SCAI 2005 . ( 2007 ., 2009 .): - 5 (), [12] . -, 30 . 17 . 714,7 ( 0,3 32 ) .

- TT - , , - / . . 2 : 1 () (0,03 /) (n=88); 2 , (0,03 /) (n=65) . - Statsoft .

2 -, 10 .

11 2/2011

. 1- - (- q , ) . 1 (1,1%) - . / 2,3% 0% .

, - , 3 (0,3 /), 5 (0,5 /) 30- . 3 1 (2,9%) -, 2- . . 2,9% 0%, . 5 1 (4,3%) , 2- . / 4,3% 0%, .

- - (1,5% 4,6%, ) . 1- 6 (6,8%), 2- 4 (6,5%) . / - (10,2% 7,7%) . 2,5 , . 3 1 (2,9%) . - . / 1- (2,9% 0%) . 5- : 4,4% 0%, , 4,4% 0% . .

klein [5] - - , . - , - . , - -

, , . - . 15 - . . [3] . Wayne L . miller . [6] - 2352 . 733 . - - . / 12 11% 4,7% (

12 2/2011

( ) ( 30-: 2,9% - 0%, 3 2,9% 0%, 5 4,3% 0%; : 10,2% 7,7%, 3 2,9% 0%, 5 4,4% 0%) . - , , . - - , .

. , - . - . 30- - 2,5 . - ( 3, 5 ) . . , .

1 . Cantor W . J . et al . For the SYmPHONY and 2nd SYmPHONY Cardiac markers Substudy Investigators . Prognostic significance of elevated troponin I after percutaneous coronary intervention // JACC . 2002; 39 . . 17381744 .

2 . Cavallini C . et al . Impact of the elevation of biochemical markers of myocardial damage on long-term mortality after percutaneous

coronary intervention: results of the Ck-mB and PCI study // Eur Heart J . 2005; 26 . . 14941498 .

3 . Giannitsis E . et al . Admission troponin T level predicts clinical outcomes, TImI flow, and myocardial tissue perfusion after primary percutaneous intervention for acute ST-segment elevation myocardial infarction // Circulation . 2001; 104 . . 630635 .

4 . Herrmann J . Peri-procedural myocardial injury: 2005 update // Eur Heart J . 2005; 26 . . 24932519 .

5 . klein L . W ., kramer B . L ., Howard E . et al . Incidence and clinical significance of transient creatine kinase elevations and the diagnosis of nonq wave myocardial infarction associated with coronary angioplasty // J Am Coll Cardiol . 1991; 17 . . 621-626 .

6 . miller W . L . et al . Baseline troponin level: key to understanding the importance of post-PCI troponin elevations // Eur Heart J . 2006; 27 . . 10611069 .

7 . morrow D . A . et al . For the TACTICS-TImI 18 Investigators . Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction . Results from a randomized trial // JAmA . 2001; 286 . . 24052412 .

8 . Oh J . k . et al . Creatine kinase release after successful percutaneous transluminal coronary angioplasty // Am Heart J . 1985; 109 . . 12251231 .

9 . Prasad A . et al . Significance of periprocedural myonecrosis on outcomes following percutaneous coronary intervention: an analysis of pre and post intervention troponin T levels in 5487 patients // Circ Cardiovasc Intervent . 2008 . . 1: 1019 .

10 . Thygesen k ., Alpert J . S ., White H . D . n behalf of Joint European Society of Cardiology/American College of Cardiology/American Heart Association/World Heart Federation Task Force for the Redefinition of myocardial Infarction . Universal definition of myocardial infarction // Circulation . 2007; 22 . . 26342653 .

11 . Wu A . H . et al . National Academy of Clinical Biochemistry standards of laboratory practice: recommendations for the use of cardiac markers in coronary artery diseases // Clin Chem . 1999; 45 . . 11041121 .

12 . 2009 Focused Updates: ACC/AHA Guidelines for the management of patients with ST elevation myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) // J Am Coll Cardiol . 2009; 54 . . 2205-2241 .

13 2/2011

. ., . ., . . , . , - . . . , . -

- - - - . - - 53 6,7 , APC, C-kit, E-cadherin .

: , , , P53.

: . 8-912-921-22-22 . E-mail: sabirov58@mail .ru

. - - , . - , - [1-3] . () - , . , , , , [6] .

- (target) . , . - (EGFR) (VEGFR), - . () (), () . -

antonov M. V., sabirov a. Kh., Mystaev o.Z.

TARGETED THERAPY COLORECTAL CANCER

Analysis of the prognostic significance of complex clinical and morphological characteristics, taking into account the expression of molecular biological markers revealed a close relationship between increased values of the epidermal growth factor and vascular endothelial growth factor with a molecular genetic status of colorectal cancer patients . molecular genetic study of colorectal cancer patients showed p53 gene mutations in exons 6 . 7, APC, C-kit, E-cadherin .

Key words: cancer, epidermal growth factor, vascular endothelial growth factor, gene mutation P53.

, , . - , , , - [4, 5, 7] .

. -- - , - .

. . - , - , - . - - - .

FOLFIRI FOLFIRI .

. -

14 2/2011

100 , . 2 , 50 . k-Ras . - , - EGFR VGFR . - 100 , k-ras . (-) 561,1 ( 29 75 ) . 5- ECOG . 2 . 100 - , . , , . - : 50 100 FOLFIRI, 50 FOLFIRI + - . , .

- - , - . 1 .

1

,

ki-67 mouse mAbmIB-1

Dako RTU

VEGF mouse mAbVG1

Dako 1:25

EGFR mouse mAbH11

Dako 1:200

- , (, -, , ) . - EGFR VEGFR : 0 , 1+ 10% , 2+ 10% , 3+

- 10% . , , EGFR VIGFR . , , ( . 2, 3) .

2 EGfR

EGFR

0 1+ 2+ 3+

(n=23) 4 19

(n=115) 29 68 18

(n=12) 4 8

: n .

3 vEGfR

VEGFR

0 1+ 2+ 3+

(n=23) - 1 3 19

(n=115) 2 25 64 24

(n=12) 2 9 1

, - . - i-67 - . i-67 - . - , : 0%-20% ; 21%-50% ; 51%-100% . - kI-67 . , kI-67, .

- - ( . 5) . . 5 , (290 ) . 53 7 . -

15 2/2011

4 KI-67

kI-67

(n=12) 12 (100%)

(n=115) 105 (91,3%) 10 (8,7%)

(n=23) 23 (100%)

5- EGfR, hvEGfR-165

(n=100)

-

-

EGFR (N=0-9,5

fmol/ml)

hVEGFR-165

(N=0-120 pg/ml)

-

535

536 -

537

538 -

C-kit12-

B-raf15-

APC

k-ras12,13-

E-cad-herin

16

10,8 130,0 4 4 9 8 2 3 4 1 35

36,7 168,0 27 54 79 42 12 18 32 26 290

15,4 174,7 11 10 21 9 7 1 14 11 8 92

6 - 6- fOLfIRI (n=50)

-

- (n -)

EGFR (N=0-9,5 fmol/ml)

hVEGFR-165

(N=0-120 pg/ml)

535 -

536 -

537 -

538 -

C-kit12 -

B-raf15 -

APC

k-ras12,13-

E-cad-herin

16

(n=4)

9,8 128,0 1 1 3 2 1 2

(n=38) 34,9 165,0 9 21 32 15 4 8 12 10

(n=8) 13,8 143,9 5 4 8 4 3 1 4 4 4

7- 6- fOLfIRI + (n=50)

-

-

EGFR (N=0-9,5 fmol/

ml)

hVEGFR-165

(N=0-120 pg/ml)

535

536 -

537

538 -

C-kit12

B-raf15

APC

k-ras12,13

E-cad-herin

16

(n=4) 9,3 125,9 3 2 1

(n=38) 34,3 161,3 5 10 13 9 2 3 6 4

(n=8) 13,3 139,2 2 2 5 2 1 3 2 1

53 7 . EGFR, hVEGFR-165 - (EGFR=36,7 fmol/ml, hVEGFR-165=168,0 pg/ml) .

2 -, FOLFIRI ( . 6), FOLFIRI + ( . 7) . 2- (): -, - , , , , . - - 6 .

, . 6, 7 , - , : - EGFR VEGFR . - ( ) .

, 6- , , EGFR, VEGFR . , - , - ( -, ki-67, EGFR, VEGFR ) ,

16 2/2011

, - . - , FOLFIRI + , , () , , FOLFIRI . - - ( ), - , .

, () FOLFIRI, 54%, 10,9 20,6 . , FOLFIRI + , 57,9%, 13,5 - 27,7 .

- , . - - , . , . , EGFR k-ras .

. - , , - , - . - , , - .

-, -, - - . - - .

- - - - EGFR VEGFR - .

, - - . - : 53 6,7 , APC, C-kit, E-cadherin .

- EGFR VEGFR - . EGFR VEGFRs . , ki-67, - , - . - - : . EGFR VEGFRs FOLFIRI + FOLFIRI - . , FOLFIRI + , - - ( ) - FOLFIRI . - .

1 . . ., . ., . ., . . // - . 2003, . 11 . C . 674- 679 .

2 . . ., . . - 2003 . ., 2005 . 265 .

3 . 2006 ( ) / . . . , . . , . . . .: . . . , 2008 . 248 .

4 . E . H . - - : , , // . . 2005 . . 6 . 2 . . 65-70 .

5 . . ., . . // , 2009 . 2 . - . 75-78 .

6 . . ., . ., . . - . / . . . , . . . .: . 2004 . . 162-167 .

7 . . ., . ., . . . // . 2010 . 2 . . 56 . . 78-80 .

8 . Oesterreich S . t al . Estrogenmediated down-regulation of E-cad-herin in breast cncer cells // Cancer Res . V . 63 . P . 5203-5208 .

17 2/2011

. ., . ., . . ; , , . ,

,

, - , . - , .

: , , , .

: . 8 (3452)-27-05-00 . -mail: nasrulla@inbox .ru

Vazhenin a. V., shanazarov N. a., Nalgieva f. h.

EFFICACY OF ENDOVASkULYARNOY HImIOmBOLIzACII IN A COmBINED TREATmENT OF CERVICAL CANCER, COmPLICATED BLEEDING

With a view to enhancing the effectiveness of combined treatment of cervical cancer, complicated bleeding, apply endovaskular chemoembolization . Study to develop a number of indications and contraindications to the use of method endovaskular chemoembolization combined treatment of patients with cervical cancer, complicated bleeding .

Key words: cervical cancer, rentgenoendovaskular intervention, chemoembolization, patomorfoz.

. - , , [4, 9] . , , - [1, 3, 5, 10, 11] . , , - . , , , . , , , - [2,6,7,8] .

. -

, , - . () . , () . 34 , - () . 35 , .

- , , - , , .

. -, Triplex Angiomatic multistar T . O . P+

18 2/2011

Siemens . - , , . - , - , . 10,0-20,0 10,0 . (Sol . Novocaini 0,5% 20,0 ) / - 6F . . . . 40 , . - .

. . . - . - (76% 40 ) . , - . - , 10-12 . , .

- . , . 10% - . 5-7 . - -6, Leica . - . , , - . . (1977) .

. - -

(), - () . Teratron Equinox mDS Nordion (Canada) 2 50 . multisourse (Germany) 5 50 . 2 24 5 25 . 2 50 5 50 .

. - ( - ; ; - ; ; I-II ); ( - ); - .

, -, , . 100% . - - .

- - , . , - 5 . - 20, 30 40 . 14 (41,2%) - ; 13 (38,3%) ; 1 (2,9%) - ; 2 (5,9%) ; 2 (5,9%) - ; 1 (2,9%) 1 (2,9%) .

1, 2 .

19 2/2011

. 1 . . -

,

. 2 . . -

,

- (n=34) , - () , .

. - 100% - . . 171,096,90 3 . - 150 200 3 23 (67,6%) . 38,2% (13) . 58,9% .

. -

, 52,9% (18 ) 47,1% (16 ) . - 44,1% (15 ), 20,6% (7 -), 35,3% (12 ) - .

- , 10 . 48 96 . .

- - , - . -, - (>0,05) . : - ( ) . - , . , - . - , , ( . 3, 4) .

. 3 . ., 42 . . III . -, . 160 .

20 2/2011

- . . (1977) . , ( IV ) ; 50% ( III ) 70% ( . 3) .

50% ( I-II ) 30% . , I , II ( . 4) .

. 4 . ., 42 - . . 2 . -, . 160

. - , . .

- - , , - , .

- - . -

- , - . , - , - , .

1 . . ., . ., . . - . // . 2010 . 1(37) . . 5-11 .

2 . . . . // . 2009 . . 4 . 2 . . 39-41 .

3 . . ., . . 2004 . // . . . . 2006 . . 17 . 3 . . 1 . 132 .

4 . . . . - ( ) // . 2008 . 2 (26) . . 27-31 .

5 . . ., . ., . . // . 2009 . . 2 . . 111-112 .

6 . . . . // . 2010 . 2 . . 106-108 .

7 . . . . // . 2009 . 3-4 . . 121-124 .

8 . . . , : . . . , 2007 . 114 .

9 . . ., . ., . . // . 2008 . . LVII . . 1 . . 36-40 .

10 . . . . // . 2008 . 1(25) . . 17-22 .

11 . . . . : // . . . 2007 . 6 . . 627-630 .

21 2/2011

. ., . ., . . , .

100 . 25 /2 , ( - ) , , - , (3 ) (12 ) .

: , , - .

: . 8-904-887-81-55 . -mail: petrovokb@mail .ru

Gamzatova Z. a., Petrov i. M, Vasilieva i. V.

ESTImATION REmOTE RESULT PREVENTIVE CONSULTANCY PATIENT WITH OVERWEIGHT AND ABDOmINAL OBESITY

As result of examinations 100 working inhabitants N . Urengoy with and BmI>25 kg/m2 is installed that use the preventive consultancy of the programs (School of health for patient in abundance masses of the body and obesity) brings about reduction of the frequency of the breaches of the feeding, overweight of the body, low physical activity and concentrations -reactive protein, as at short-term period (3 months) so at more remote period (12 months) .

Key words: preventive consultancy, obesity, - reactive protein.

. - , - 45 56% 56 62% [1, 5] . - , [3, 10] . - [1, 8], , / . - . () () . , [4, 14] .

, , , - [13] - [15], [9, 11] .

, - , , , , , . , , - , - .

. - (3 ) (1 ) - ( ) .

. 100 . (), - . ( 25 /2) - ( 94 .

22 2/2011

80 . ), 28 52 ( 42 38 46 ), - - - - - . , , . ( . .) . - 43 (43%) 57 (57%) . - : ; - , , . : - ( ); CINDI; - , -

(-hs) Humalazer 3000 .

- , : 1 ( -) 50 ( 40,5 , 36 44 ) - , - . 2 50 ( 43 , 37 49 ), - ( -) . - - [2] , . .

1,

Me(25-75 )

1 (n=50) 2 (n=50)

mann-Whitney

, 40,5 (36-44) 43 (37-49) p>0,05

, /2 28,06 (25,9-30,6) 30,2 (28,7-32,9) p>0,05

, / 4,75 (4,57-4,86) 4,8 (4,53-4,89) p>0,05

, / 1,66 (1,38-1,73) 1,54 (1,4-1,68) p>0,05

, / 3,29(2,98-3,47) 3,19 (2,6-3,52) p>0,05

, / 1,04 (0,69-1,33) 1,14 (0,72-1,35) p>0,05

2,1 (1,99-2,75) 2,48 (2,1-2,85) p>0,05

2 -

1 (n=50) 2 (n=50)

6 12 6 12

n % n % n % n % n % n %

- / -

41 82 36 72 43 86 42 8419*

p1-2

23 2/2011

2010 [3] . 8-10 (5-7 80-90 ), 10-12 .

, , . -, , , - ( . 1) . 34% 1 36% , , - , - : 5 1 2,5 1 1 , - 10 20 / . 3 , - . - - ( ) 3 12 - , .

. - 2- - . - ( . 2) - / , - 3 . 12 - . , - ( 35% ), - ( 300 / .), ( 10% ) . - 50% , (p

24 2/2011

12 - . ( - ) - - , , - - , (3 ) (12 ) .

1 . . ., . ., . . . - - // . 2002 . 10 . . 45-49 .

2 . . . . . - 2008 . 188 .

3 . - . / . . . . ., 2010 . 118 .

4 . . ., . . . .: media medica, 2004 . 168 .

5 . . ., . ., . . . : , -, - // . 2006; 4(60) . . 45-50 .

6 . . ., . ., . . - // . . 2004 . 3(4) . . 4-11 .

7 . Harris m . m ., Stevens J ., Thomas N . et al . Associations of fat distribution and obesity with hypertension in a bi-ethnic population: the ARIC Study . // Obesity Research 2000; 8: . 516-524 .

8 . Hubert H . B . et al . Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study // Circulation 1983; 67 . . 968-977 .

9 . krauss R . m ., Blanche P . J ., Rawlings R . S . et al . Separate effects of reduced carbohydrate intake and weight loss on atherogehic dyslipidemia // Am J Clin Nutr 2006; 83(5) . . 1025-33 .

10 . mokdad . . et al . The continuing epidemics of obesity and diabetes in the United States // JAmA 2001; 286: . 1195-1200 .

11 . Noakes m, keogh JB, Foster PR, et al . Effect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese women // Am J Clinical Nutrition 2005; 81(6) . . 1298-1306 .

12 . Smith R . D ., Jeffery R . W ., Hellerstedt W . L . et al . A randomized trial of counseling for fat restriction versus calorie restriction in the treatment of obesity // International Journal of Obesity . 1995 . 19 . . 132-137 .

13 . The Trials of Hypertension Prevention Collaborative Research Group . Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure // Arch Intern med 1997; 157 . . 657-667 .

14 . Tremblay A . J ., Despres J . P ., Pich m . E . et al . Associations between the fatty acid content of triglyceride visceral adipose tissue accumulation, and components of the insulin resistance syndrome // metabolism 2004; 53 . . 310-17

15 . ziccardi P ., Nappo F ., Giugliano G . et al . Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year // Circulation 2002; 105 . . 804-809 .

25 2/2011

. ., . ., . . - , . -; , .

- . .

: , , .

: . 8 (3452) 32-97-89 . -mail: pan_zuban@msn .com

. - () . , -, , [1, 2] . . - - N . G . kock [3], . - - , 45-60 , , - [4] . , ( ) . , - [5] .

[6] . - .

. - .

. - 108 , - 1999 2011 . - 65 (60,2%) . 38 (58,5%), 27 (41,5%) . 30 (46,1%) 30-35 (1 ) . 17 (56,7%), 13 (43,3%) . 21 69 52,54,3 . 35 (53,9%) - 45-60 (2 ) . : 21 (60,0%), 14 (40,0%) .

Zuban o. N., Chotchaev r. ., Popov i. b.

THE ROLE OF THE LENGTH OF ILEAL LOOP USING FOR CYSTOPLASTY IN mETABOLIC AND URODYNAmIC DISORDERS DEVELOPmENT.

The present study is devoted to analysis of metabolic and urodynamic complications following ileocystoplasty depending on the length of the intestinal graft . Advantages of shortened versus standard ileal loop are shown .

Key words: ileocystoplasty, microcystis, metabolic acidosis.

26 2/2011

27 72 (50,73,8) . (38-58,5%) (20-30,8%) . , , 4 . , - - .

, - - ( 15-20 ) - / . (), . (IPSS) . , 0 5 . , 0 35 . (qOL) , 6 (6 ) (0 ) . - - ( ) 1-2 .

. - () 15-20 6-12 . 1 2 . , - , - , , Cl- ((

27 2/2011

. 3 . , - . , , : 10,10,38 8,20,26 - (p

28 2/2011

. ., . ., . ., . ., . . , .

- () () . , , .

: , , -

: . 8-922-266-24-17 . -mail: yekaterina@rambler . ru

. - (), , , - - , , - [14] . , - (), (), , [7, 9, 11, 17, 19] . , 7- , , (JNC 7) - [20] . - , - -

. , - [5, 6, 12] . , [2, 18] . , , , . 50% [21] . - , , . , - , . - , , [13, 15] . - , , , - [8] .

ibragimova E. a., Klyasheva J. M., Klyashev s. M., Kalinina V. l., triodina o. V.

THE FREqUENCY AND THE NATURE OF CARDIAC RHYTHm AND CARDIAC CONDUCTION DISTURBANCE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THE OBSTRUCTIVE SLEEP APNEA SYNDROmE BY 24-mONITORING OF ECG

In this article is resulted the estimation of the parameters of the 24-hour ECG monitoring in patients with arterial hypertension (AH) and the obstructive sleep apnea syndrome (OSAS) . According to the results of the 24-hour ECG monitoring we noted that obstructive sleep apnea in patients with AH is a significant induction factor of cardiac rhythm disturbance in the form of supraventricular and ventricular arrhythmia, including high gradation .

Key words: arterial hypertension, obstructive sleep apnea syndrome, 24-hour ECG monitoring.

29 2/2011

- , - [16] . , , , - - .

, - .

. - .

. , . - .

. - 107 I II 35 59 ( 48,11,2 ) . 63 44 . , - : I II ; . : III ; , , , ; 3 ; , , , ; - (- , , , , -, , , , - ) . : , . - / () [10] . - 2 . 64 I II ( 37 27 , 241,7 ) . 43 I II ( 26 17 , 3,90,2 ) . , .

- , ( , 2004) , , , - - . - PulseOx 7500 SPO medical (-) . 2 . , (- V2 V5, ) [1] . SPSS for Windows ( 10 . 0) . - [3] . - mm . t .

30 2/2011

, - .

1

(-%)

+

(n=64)

(n=43)

53 (82,8)* 28 (65,1)

23 (35,9)* 7 (16,3)

29 (45,3) 15 (34,9)

2 (3,1)

35 (54,7)** 8 (18,6)

17 (26,6)* 3 (7,0)

13 (20,3)** 1 (2,3)

1 (1,6)

8 (12,5)

7 (10,9)

() 14 (21,9)* 4 (9,3)

7 (10,9) 2 (4,7)

( )

4 (6,3) 1 (2,3)

1 (1,6)

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: *

31 2/2011

- . - , - . - - , , - . , - , , - [23] .

. - , - . - , - . , , - , . , , - .

1 . . . . .: -

, 2003 . 340 .2 . . ., . .

- // . 2007 . 7 . . 43-45 .

3 . . . . .: , 2002 . 312 .

4 . . ., . ., . . // Consilium medicum . 2007 . 9 . 8 . . 98-102 .

5 . Adlakha A ., Shepard J . W . Jr . Cardiac arrhythmias during normal sleep and in obstructive sleep apnea syndrome // Clin . Chest med . 1992 . Vol . 13 . P . 437-458 .

6 . Association of nocturnal arrhythmias with sleep-disordered breathing: The Sleep Heart Health Study /R . mehra et al // Am . J . Respir . Crit . Care med . 2006 . Vol . 173 . P . 910-916 .

7 . Association of sleep-disordered breathing, sleep apnea, and hypertension in large community-based study . Sleep Heart Health Study /F . J . Nieto et al // JAmA . 2000 . Vol . 283 . P . 1829-1836 .

8 . Bridgman J . C . Severe nocturnal bradycardia with daytime tachycardia in obstructive sleep apnea / J . C . Bridgman, W . F . Heddle // med . J . Aust . 2006 . Vol . 184 . P . 93-94 .

9 . Cardiovascular risk factors and mortality in patients with coronary heart disease /C . Prugger, J . Wellmann, J . Heidrich, S . m . Brand-Herrmann, U . keil // Eur . J . Epidemiol . 2008 . Vol . 23 . P . 731-737 .

10 . Effects of sleep posture on upper airway stability in patients with obstructive sleep apnea /A . m . Neill, S . m . Angus, D . Sajkov, R . D . mc Evoy // Am . J . Respir . Crit . Care med . 1997 . Vol . 155 . . 199-204 .

11 . Endeshaw Y . W ., Bloom H . L ., Bliwise D . L . Sleep-disordered breathing and cardiovascular disease in the bay area sleep cohort// Sleep . 2008 . Vol . 31 . 4 . P . 563- 568 .

12 . Grimm W . Obesity, sleep apnea syndrome, and rhythmogenic risk / W . Grimm, H . F . Becker // Herz . 2006 . Vol . 31 . P . 213-218 .

13 . Gulleminaut C ., Connolly S . J ., Winkle R . A . Cardiac arrhythmia and conduction in the sleep in 400 patients with sleep apnea syndrome// Am . J . Cardiol . 1983 . Vol . 52 . P . 490-494 .

14 . Guilleminault C ., Tilkian A ., Dement W . C . The sleep apnea syndromes . // Am . Rev . med . 1976 . Vol . 27 . P . 465-484 .

15 . Hemodynamic in sleep induced apnea: Studies during wakefulness and sleep / Tilkian A . G . et al . // Am . Intern . med . 1976 . Vol . 85 . P . 714-719 .

16 . Hoffstein V ., mateika S . Cardiac arrhythmias, snoring, and sleep apnea // Chest . 1994 . Vol . 106 . P . 466-471 .

17 . kapur V . k ., Resnick H . E ., Gottieb D . J . Sleep-disordered breathing and hypertension: does self-reported sleepiness modify the association?// Sleep . 2008 . Vol . 31 . 8 . P . 1127-1132 .

18 . koechler U ., Schafer . Is obstructive sleep apnea (OSA) a risk factor for myocardial infarction and cardiac arrhythmias in patients with coronary heart disease // Sleep . 1996 . Vol . 19 . P . 283-286 .

19 . Nicholas W . T ., Bonsignore m . R . Sleep apnea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research prioritets // Eur . Respir . J . 2007 . 29 . P . 156-178 .

20 . Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure // Hypertension . 2003 . Vol . 42 . P . 1206-1252 .

21 . Sleep apnea and cardiovascular disease /k . Somers et al . // Circulation . 2008 . Sept . 2 . P . 1079-1111 .

22 . Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the Sleep Heart Health Study /E . Shahar et al . //Am . J . Respir . Crit . Care med . 2001 . Vol . 163 . P . 19-25 .

23 . Sympathetic nerve activity during sleep in normal subjects / V . k . Somers, m . E . Dyken, A . L . mark, F . m . Abboud // N . Engl . J . med . 1993 . Vol . 328 . P . 303 .

32 2/2011

. ., . ., . ., . ., . . , .

,

3- -, , 48%, 68% 92% . 90-100% , , - .

: , , .

: . 8-950-513-08-55 . -mail: petrovokb@mail .ru

Kolinko l. P., Nazarenko s. V., Gazizova d. N., Petrova Y. a., Medvedeva i. V.

THE CHARACTERISTIC NUTRITION STATUS AT THE PREGNANT AND LACTATION WOmEN LIVING IN CONDITIONS OF THE NORTH

As a result of a complex estimation food of pregnant women in 3 trimester of the pregnancy, living in North, decrease reduction caloric content of daily diet in group of the alien population 48 %, indigenous population 68 % and in group young pregnancy 92 % . Decrease proteins are marked at 90-100 %, minimum quantity of vitamins and mineral substances fixed at patients in group young pregnancy .

Key words: pregnancy, food, Far North.

. . - , , , , , [4, 5, 8] . , [1, 10] .

, , , , - [2] . , - - , [6 . ] .

-,

- , , , . -, -, . , , - [3, 6, 7] .

. - .

. 75 - (30-33 ), . . 16 34 23,95,5 , 13,68,6 . 3 , 25 : 1- 18 , -, ; 2- 18 ,

33 2/2011

, () . 3- - , 18 , - , - . 1 . - , ( . ., 1998) . - 3 , .

- , ( 2 .3 .1 .2432 -08) - ( . . ) 18 .12 .2008 .

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. - 3- , , - , ( . 2) . - 3- 2086,1276,5 / ., (p

34 2/2011

, , - . 92% 3- , - 100% 70-90% .

3 ( . 3) . - , 2700 / ., 40% 1- , 2- 80% 3- 64% . , . , - 42,14,0%, 84% 1- , 96% 2- 3- 88% .

- - , 3- . - 2- 3-

100%, 100% 96%, , 92% .

, - , -, , . . . - - , . . 95% ( . 1) .

. 1 . .

2-,

3- , (Ms)

(2 )

(n=25)

- (n=25)

(n=25)

, /

2550 2582,9345,4 2357,58298,6 2086,1276,5*

, 96 62,910,5 62,111,4 53,79,6*

/, % 12 9,91,6 11,72,4 10,31,9

, 85 101,517,4 86,315,4* 81,314,6*

/, % 30 36,64,6 35,94,2 35,43,9

, 348 326,637,6 244,729,5* 259,330,5*

/, %

- 52,56,8 51,04,7 53,4,9

, - 3410,8 30,29,8 26,38,7

/, % 10 11,62,2 12,92,5 11,31,9

, - 27,95,6 25,14,6 25,63,9

/, % 6-10 10,81,9 9,41,7 9,91,8

, . . 1000 776,9254,7 687,8189,6 634,8123,8*

1, 1,7 1,110,8 0,930,67 0,980,56

2, 2 1,270,76 1,20,54 1,10,69

, 22 15,63,5 14,42,8 13,82,6

, 100 112,235,7 109,525,3 103,122,7

, . . 17 22,84,7 23,063,9 18,23,8

, 1300 880,4306,5 873,7296,3 876,5368,4

, 33 22,89,5 19,110,4 18,48,5*

, 450 365,195,7 278,494,6 301,3101,3

, 1000 1042,4232,4 1060,8196,8 959,8165,7

, 15 10,874,5 9,53,7 8,94,3

: p

35 2/2011

3-, ,

(Ms)

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1-6 .)

(n=25)

- (n=25)

(n=25)

, / 2700 2804,7476,9 2424,6398,8* 2501,2465,7

, 106 73,218,7 60,9 20,7* 70,718,6

/, % 12 10,22,3 10,52,4 12,31,8

, 88 133,428,7 95,225,7* 116,619,6

/, % 30 41,54,3 37,73,9 42,14,0

, 358 323,547,8 314,753,6 259,343,8

/, % 46,35,2 52,14,8 44,64,7

, 57,518,9 46,114,6* 48,715,8

/, % 10 18,86,5 12,74,7* 13,45,1*

, 31,47,5 37,96,4 37,66,3

/, % 6-10 9,42,5 11,21,9 12,52,6

, . . 1300 1110,1354,7 965,3246,6 863,72,54,7*

1, 1,8 1,410,48 1,330,39 10,36

2, 2,1 1,700,64 1,140,21* 1,560,32

, 23 16,113,6 14,73,3 14,54,1

, 120 78,645,4 61,923,7 79,730,4

, . . 19 31,87,8 34,28,3 29,17,5

, 1400 992,8345,7 678,1256,8* 679,0286,9*

, 18 17,83,5 16,62,9 17,04,2

, 450 372,065,8 326,556,8 361,762,9

, 1000 1403,1245,8 944,5198,7* 1139,2212,5

, 15 10,874,3 9,763,8 10,14,4

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36 2/2011

. ., . ., . . . - , . --

12,5%, , . II III .

: , , , .

: . 8 (863) 253-83-96 . -mail: rnioi@list .ru

Nerodo G. a., Kalabanova E. a., levchenko N. E.

THE ANALYSIS OF TERmS OF mETASTASES OCCURRENCE AND SURVIVAL OF PATIENTS WITH mETASTATIC CERVICAL CANCER DEPENDING ON VARIOUS FACTORS

The rate of metastasizing is 12 . 5 %, average term of metastases occurrence and survival depend on stage, depth of tumour invasion and performed treatment . Inclusion of chemotherapy into treatment scheme at st . II and III of malignant disease considerably increases the patients life expectancy .

Key words: cervical cancer, metastases, survival, treatment.

. . 2008 13807 [7] . - , - ( 35 ) [13, 8, 9, 14, 1] .

- [5] . 2006 4,6%, 30 8,5% [16] . 6000 [2] . . . (2003) [11] - I II 92,8% 85,4% , - 89,4% 80,1% . . . (1975) [12] - III 64,2%, 52,8% .

, , 30-45% [3] .

, , . - , [15] . . . , . . , . . (2010) [10], - 67,7% . - 13-23% 57% [4] . . - . . . (2009) [6], -, 9,7 , 15,9 . -, .

. - , , - .

. 164 , - -

37 2/2011

- 2000 2010 , 1310 , . - , - ( Statistika 6 .0) . (EFS event free survival) .

. 12,5% . I - 8 290, 2,8% I . II 49 482, - 10,2% . 496 III 75 (15,1%) - . IV 32 42 (76,2%) .

164 I 8 (4,9%), II 49 (29,9%), III 75 (45,7%), IV 32 - (19,5%) . , 32 IV 16 III , , . 116 - , , .

: I - 34,25 , II 20,73 , III 17,08 . - . , 1 I - 37,4 , 1 22,3 . II 1 21,1 , 1 - 18,8 . III 1 , , 19,9 , 1 15,3 .

II 21 , 19 . III 18 , - 14 .

, II III , . , , .

- . - - . . , I 86%, II 48%, III 22%, IV -, 11% . : I 19%, II 8%, III 5 .

, , . - , . - II , 1 65,5%, 1 41,2% . , - II 1 . III 1 - 26,2%, 1 22,4% .

- . II 1 - 19,0%, 1 10,5% . III 1 3 7,1% , 1 3 .

( ) -

38 2/2011

: , , - . -, - . , - - . II . 70,8% , 39,7% (

39 2/2011

. ., . ., . ., . ., . . , .

300 / . 3 , , , (, IL-6) , - .

: , , .

: .: 8-904-887-81-55 . -mail: petrovokb@mail .ru

slepov M. N., Pelevin a. r., Gooz G. G., tchernak a. Y., Petrov i. M.

POSTPRANDIAL LEVEL OF INFLAmmATION mARkERS AT PATIENTS WITH PREDIABETES AGAINST USE OF VARIOUS PROGRAmS OF CORRECTION.

Application acarbose in a doze of 300 mg / day within 3 months at patients with prediabetes in combination with reduction of the diet accompanied the reduction, concentrations marker inflammations (CRP, IL-6) and atherogenic lipid fraction in postprandial period, not reducing BmI .

Key words: acarbose, prediabetes, markers of inflammation.

. - - 2 . , , - , . . , - , - [1, 5, 6] .

, , , , - . - ( , , , ), , , , , , [7, 14, 15] .

, - , - ,

[13], , - [8] . - 2 () [8, 11], [2] . [11, 12] - - - .

, - - , - - . (), , .

. - , - .

40 2/2011

. 57 () () 37 56 , - 45,65,8 , 73,2% (36/57), 36,8% (21/57), . . . - ( < 7 . 0 /, 2 75 7 . 8 /, < 11,1 /), (>27 /2 / 94 , 80 ), >129/84 . . .), ( 5,0 /); > 1,7 /

41 2/2011

- U- mann-Whitney . 2 . - (ms) . .

. - , , , , , - 3- . , 1- (p

42 2/2011

. 2 - 22,1% (

43 2/2011

. ., . . , .

3% . - , , , . - .

: , , .

: 8 (3532) 63-69-80 . E-mail: sagel .8181@mail .ru

sagitova E. r., bagirova G. G.

CARDIOVASCULAR mANIFESTATIONS OF ATHEROSCLEROSIS IN PATIENTS WITH RHEUmATOID ARTHRITIS

Among RA patients with cardiovascular complication were observed in 3% . In their development play a role body mass index, hypertension, dyslipidemia, disease activity and severity index . Predictors of these complications are atherosclerotic changes in carotid arteries . The degree of severity of atherosclerotic lesions occurs in older people, with high activity and severity of the process .

Key words: rheumatoid arthritis, atherosclerosis of the carotid arteries, cardiovascular pathology.

. () - , - () - [3] . 10 [8, 15] . - - 60% [12, 13] .

, -, ( , , ) [10, 16] . - , - , [8, 16] . - , , , - . -, - , [1, 3] .

- - .

. - - - .

. . - - , ( () - ()) . 1729 , . . 2005-2007 . (847 882 , 47,54,3 ) . , 70% , - . 281 , - 2002 2006 . (196 85 , 56,23,5 ) .

100 (1987) . 21 84 ( 53,410,1 ) .

44 2/2011

(86%) . ( 6 35 ): - 1 5 10 . , , DAS 28, , II , III . 31% . , -, , - (: , , -) (), () 60 (- 1 5 ) . 5 4 , , . 2 : 1- (19 ) 7,5-15 , 7,5-15 ; 2- (17 ) + 6-8 . ( ) - - .

. DAS 28 . . . (2004) . Steinbroker . - SCORE [7] . - () > 5% , 5% 10 .

- , , , , -, -, - . - - , , , , , - . Statistica 6 .0 . , , 2 . - -,

- - [5] .

. , , - , (), 0,3%, 0,05% . - . 100 , , , ( ) 3%, - qUEST-RA [14] .

, - - 0,9 / (ESH/ESC, 2007) . - () 1,5 ( ) , 50% - ( ) . - , - .

100 20 - , 1 . 2 21 , , - , (

45 2/2011

, ( DAS 28 ) . , DAS 28 - , 1 2 (=0,025) . 3 2 , , (64,4% 30% ) . . 29,8% , 1,7%, , , 3 , (5% 15% -) . , (=0,03) .

, , - . , , , . - , - (57,57,2), (64,37,5) (, , ), , , . - .

10- - , - SCORE, - , (56,6 30% ) . - 1 3 -, 3 , 13,5% . , 10- - (=0,005) .

, ( ) . 100 3 - : 2 ( 58 66

) , 3 5 ; 54 - , - 1,5 . , 3 . . 71% 100% (11%) (27%), (49%), , (20%), - / (8%) . -, - -, (=0,02) .

- (82%), - (35% ), . . - , , . ST 21% 100 . 16 - , () . (11 ) . 3 - 2 , . 5 21 , . ST 1 3, - (3-4 ) .

, - . (100) 30% : 7 2 23 3 . - , , (=0,006) (=0,01) . , - , (=0,04) .

46 2/2011

: 1 +, 2 + .

- , . - (=0,04) . - , : - (>0,05) . - . - 12- .

. , - , , . 3% 5 . (, , ), - ( ) .

- , , . , . - ( , ), . - . - . , , , - . . -

, .

1 . . ., . . , . .: , 1995 . 304 .

2 . . . / : . : , 2004 . . 163-195 .

3 . . . -: // . . 1998 . 9 . . 92-95 .

4 . . . . / . . . , . . . .: -, 2008; 720 .

5 . . . . STATISTICA . .: , 2002 . 312 .

6 . Arnett F . C . et al . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis // Arthr . Rheum . 1988 . Vol . 31 . P . 315-324 .

7 . Conroy R . m . et al . Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project // Eur . Heart J . 2003 . Vol . 24 . P . 987-1003 .

8 . Goodson N . Coronary artery disease and rheumatoid arthritis // Curr . Opin . Rheumatol . 2002 . 14 . P . 115-120 .

9 . Goodson N . J . et al . mortality in Early inflammatory polyarthritis . Cardiovascular mortality is increased in seropositive patients // Arthritis Rheum . 2002 . Vol . 46 . P . 2010-2019 .

10 . kitas G . D ., Erb N . Tackling ischaemic heart disease in rheumatoid arthritis // J . Rheumatol . 2003 . Vol . 42 . P . 607-613 .

11 . mancia G . et al . Guidelines for the management of arterial hypertension . The task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) // Eur . Heart J . 2007 . Vol . 6 . P . 175 .

12 . meune C . et al . Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: a systematic review and meta-analisis of cohort studies // Rheumatology . 2009 . Vol . 48 (10) . P . 1309-1313 .

13 . myasoedova E ., Gabriel S . Cardiovascular disease in rheumatoid arthritis: a step forward // Curr . Opin . Rheumatol . 2010 . Vol . 22 . P . 342-347 .

14 . Naranjo A . et al . Cardiovascular disease in patients with rheumatoid arthritis: results from the qUEST-RA study // ArthritisRes . Ther . 2008 . Vol . 10 . P . 30 .

15 . Riise T . et al . Total mortality is increased in rheumatoid arthritis . A 17-year prospective study // Clin Rheumatol . 2001 . Vol . 20 (2) . P . 123-127 .

16 . Van Doornum S ., mcColl G ., Wicks I . P . Accelerated atherosclerosis . An axtraarticular feature of rheumatoid arthritis // Arthritis Rheum . 2002 . Vol . 46 . P . 862-875 .

47 2/2011

. ., . ., . ., . ., . ., . . , .

-3 1 / . 3 - (, Apo / Apo A1), ( 30% ) . - , , - .

: -3 , , , -.

: . 8-904-887-81-55 . -mail: petrovokb@mail .ru

slepov M. N., Pelevin a. r., Gooz G. G., tchernak a. Y., Medvedeva i. V., shalomov i. f.

CORRECTION mETABOLIC PARAmETERS AND ENDOTHELIUm FUNCTION DYNAmIC IN OBESE PATIENTS, LIVING OF THE NORTH

Omega-3 PUFA 1 g/day intake during 3 months causes reduction of lipid profile atherogenity, 30% leptin concentration decrease (compared to baseline), and reduction of insulin resistance rate . These effects are accompanied by endothelium-dependent dilation increase in brachial artery, while inflammatory markers plasma levels rates and intima-media complex stay stable .

Key words: omega-3 PUFA, obesity, endothelium-dependent dilation, complex intima-media.

. - , , [4] . - , [9], , - [11] .

, - [3], , , - - [6] . , - [2] . , - , , - . NO-, -

- , [8] . , - , , , .

- [12], -, [4] . - -3 () - , GISSI -3 .

. - -3 , - , - .

. -

48 2/2011

, . , . - - ( , , , ), ( , , , ), ( , ), ( ) . ( 94 , 80 ), 10 . : 60 , , -, , (, ) , , , - .

60 29 58 , 45,47,5 , 70% (42/60), 30% (18/60), - . 1 . 93,3% (56/60), 76,7% (46/60), - 50% (30/60), 40% (24/60) 20%, . - 83,3% (20/24) .

A1 ( A1, B), - - (), -6 (-6), . - - - - () - () , Acuson Sequoia -512 (USA)

7 , - . , ( , , ), . 10 %, , 1,0 - , 1,01,4 , 1,4 - [5] .

- -3 30 . 1 - ; 2 - -3 () 1 1 3 . - , 1 90% -3 -, 84% , 6% -3 . Statistica v . 6 . - . - U- mann-Whitney . 2 . - (ms) . .

. - , - 1-, 2- ( . 2) . , 2- , - , 19% (p

49 2/2011

-3 46,7% (14/30) 26,7% (8/30) . , - - [3] . - , - -, , [10] .

- , , . : , - . -, , -6 . , -3 1 / 3 , .

-, 3 , - [7] . ,

3 - , - 4, . , (p

50 2/2011

, , , AmORIS . , , Apo - . Apo / Apo A1 , -, , . Apo / Apo A1 25%, - , -3 . - - , Apo / Apo A1 ( 0,9 , 0,8 ), 60% (18/30) 36,7% (11/30) .

, , 2- - , 4,960,5 . - , 11,41,91%, (p1-2

51 2/2011

. ., . ., . ., . . ; , .

,

, - . , -: , .

: , , , , , .

: . 8-909-188-71-33 . -mail: ushakova_tgma@mail .ru

ushakova s. a., Kulichenko M. P., Petrushin a. d., Zhuravleva t. d.

FEATURES LIPID, CARBOHYDRATE AND PURINE mETABOLISm IN ADOLESCENTS WITH ARTERIAL HYPERTENSION AND ABDOmINAL OBESITY

Features lipid, carbohydrate and purine metabolism an exchange at teenagers with an arterial hypertensia and abdominal obesity are studied . It is shown that hypertension in boys and adolescent girls with early development and progression of obesity in adolescence is formed against the background of a high concentration of metabolic risk factors for cardiovascular disease: atherogenic dyslipidemia, and hyperuricemia options, which are based on hyperinsulinemia and insulin resistance .

Key words: teenagers, arterial hypertensia, abdominal obesity, dyslipidemia, hyperuricemia, insulin resistance.

. - , , () - (), - - [3, 6, 11] . , -, - [1, 7-9] . -, , , , , - , , , - [10, 12, 13] .

. - (, -, , ) - .

. .

2007-2010 . 126 (89 37 ) 12 17 () - () . : 1) 12-17 II-V ; 2) - - 2 (>2,0 SDS) - > 90- ; 3) () - , ( / 95o/oo , ) ; 4)

52 2/2011

. : 1) ; 2) , , , .; 3) (, , - ); 4) - ; 5) .

50 (26 24 ) 12-17 , - - , - 1 2 . - . , (), , (), (/) - ( , ) .

- - II , (2009) [4] . - (), () () - () - Hymalyzer-2000 . ( ) - 2,2, ( ) : (/)= (/2,2 + ) . - () : = ( )/ . () - () .

() - , per os 1,75 ( 75 ) 10- - . (BioSystems S .A .,Spain) . (2006) .

() - - DRG Instruments GmbH () . HmA-IR (Homeostasis model Assessment Insulin Resistance) Go INSo/22,5; Go , INSo .

- Excel 7 .0 SPSS 17 .0 . - () - (SD) . - - t- () 95% .

. - (n=89 ) - 15,22,4 , (n=37 ) 14,52,3 . 6,13,2 , 8,54,1 . 6,52,8 , 7,23,8 . II-III . () () - 34,64,1 /2 108,210,1 , , 33,95,5 /2 95,514,07 , . (92%), , .

- ( 13,02,5 ) . () () 136,114,3 . . 78,37,9 . ., -, 127,311,6 . . 62,57,3 . ., . , (=0,001) . 29 (32,6%) 18 (48,6%) . , I II ( 33,7% , ), I ( 46% ) II ( 5,4% ) .

- , .

53 2/2011

(=0,029), (=0,049), (=0,034) (

54 2/2011

.3, - , () - , (

55 2/2011

. ., . . , , .

103 , on lay, . . . on lay, 27,9%, 15,7%, 3,6 , - .

: , .

: . 8-842-262-51-22 . -mail: charyshkin@yandex .ru

Charyshkin a. l., Vasilev M. N.

RESULTS HERNIA PLASTIC THE POSTOPERATIVE mEDIAN ventral THE HERNIAS

Results of treatment of 103 patients with postoperative median ventralthe hernias, operated on a method on lay, to a way to V . I . Belokoneva and the way developed by us are investigated . The conclusion is drawn that, in comparison with hernia plastic on lay, use of the developed way allows to lower authentically the general complications on 27,9 %, local complications on 15,7 %, hospitalization terms for 3,6 days, and to exclude relapses .

Key words: postoperative ventral a hernia, hernia plastic.

. , - () 2-20% , [1, 2] . 60% [3, 11] . - , 11,4-23,3% [4, 5] . 1-5% [2, 6, 11] . - . - [7, 10] . , , , , , , 18,6-67% [8, 9] . - [7] .

. - - .

. 103 ,

- 2006 2011 . 57,310,1 . . 1 . 62 (60,2%) , 34 (33%), - 33 (32%), 25 (24,3%), 13 (12,6%) ( . 2) .

1

45 45-59

60

1 (0,9%) 6 (5,8%) 3 (2,9%)

10 (9,7%) 40 (38,9%) 43 (41,8%)

11 (10,6%) 46 (44,7%) 46 (44,7%)

SWR-, - J . P . Chevrel A . m . Rath, XXI (1999 .) V - [10] . SWR- . 3 . 28 (27,2%) , 15 (14,6%) . . - 20 , - (

56 2/2011

2010112912, 02 . 04 . 2010) . 1 20 . . , 2 - 63 on lay . .

2

n

62 (60,2%)

34 (33%)

(, ) 33 (32%)

25 (24,3%)

, , 14 (13,6%)

9 (8,7%)

13 (12,6%)

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18 (17,5%)

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W4 15

-

15 (14,6%) 41 (39,8%) 24 (23,3%)23

(22,3%)

- (), - 2- . . ., . ., 1,36 . . = 1 . . , 12 . . Sugrue m ., Hilman k . m . (1998) . 3, 7, 10 14 . - . - () . . . (1983), .

. : 12 5-7 . -

30 , . - , , , 5-7 . - 2%-1,0 2-3 , - 50% 2 .0 . ( 0,05%-1 .0), () . - -02 . 1 10-15 , 5-10 . - . , .

( 2010112912) - . - - . - . , , . . . , ( . 1) .

. 1 . . 1 ; 2 ; 3 - ; 4 ; 5 ; 6 ; 7 ; 8 ; 9

57 2/2011

. 1 74,721,2 , 2 69,728,6 . 6619 -, 8,7 1, 3,7 2; (p>0,05) . 1 5,41,3 , 2 5,21,5 . 4,30,8 , 1,1 1 0,9 2; - (p0,05) . - 2-3 : 1 37,0 , 2 36,9 . 2-3 37,5 , 0,5 1 0,6 2 .

, : 1 12 , 2 15 . 10 , 2 , 1 5 , 2 . W1 SWR- 2, , . 1,

. . [2], - 1 .

2 W3 2 16,70,9 . .; W4 - 3 21,41 . . W3 - 1 14,8 0,9 . ., , 2 1,9 . ., (p

58 2/2011

(p0,05) . 2 1 (1,6%) , .

. - - - , 54,8% , 1,6 , on lay . - , , , W3 1,9 . ., W4 2,3 . on lay . 15%, 15% . . ; 27,9%,

15,7% on lay . on lay, - 3,6 .

1 . . ., . ., . . . // . 2004 . 2 . . 6-12 .

2 . . ., . ., . . // . 2008 . 11 . . 44-46 .

3 . . ., . ., . ., . . , - , . ., 2007 . 24 .

4 . . ., . ., . . - . .: , 2003 . 228 .

5 . . ., . ., . . // - . 2006 . 3:11 . . 16-17 .

6 . . . . .: , 2009 . 440 .

7 . . ., . . - // . 2008 . 1 . . 66-71 .

8 . . ., . ., . . - // . 2004 . 1 . . 5-10 .

9 . . ., . . : - // . 2006 . 6 (52) . . 221-225 .

10 . mcGreevy J . m . et al . Study comparing the complication rates between laparoscopic and open ventral hernia repairs // Surg . Endosc . 2003 . Vol . 17, 11 . P . 1778-1780 .

11 . Napolitano L . et al . Use of prosthetic materials in incisional hernias: our clinical experience // G . Chir . 2004 . Vol . 25, N 4 . P . 141-145 .

59 2/2011

. . . . . . , .

- , . - (CmV, HCV-1) , . pneumoniae .

: , -, , , .

: . (342) 236-86-21 . E-mail: ashavrin1@mail .ru

shavrin a. P.

THE VALUE OF INFECTIOUS AND NON-INFECTIOUS FACTORS IN THE PROCESS OF ATHEROSCLEROSIS DEVELOPmENT

The intima-media complex thickness is tightly associated with infectious, metabolic and immune parameters at all the stages of atherosclerotic process development . The relationship of viruses (CmV, HCV-1) with vascular wall is obligate in all groups, and l . pneumoniae only in persons with subclinical atherosclerosis and in patients with myocardial infarction .

Key words: atherosclerosis, intima-media complex, latent infections, risk factors, inflammation.

. , : - [10], [6] [9] . , [19, 20,12] . , [21] . , [4,5] . - : - (CRP), (IL1, IL6, IL8, IFN, TNF-) [7] . , - . . - , , , - .

. - .

. 342 , 25 60 , 43,70,5 , . 4- . - . 23 , 8 15 , 43,82,1 . , - - () . 272 , 110 152 . 43,10,6 . 29 , 15 14 , - . 44,31,5 . 18 - ( ) . 14 4 . 51,22,3 .

- -

60 2/2011

(), [15], - , . (), () (-) . - (-) - (-) [3] . - (CRP), : - (TNF-), - (IFN-), (IL) -1, -4, -8 . CRP () - SeroELISA Diagnostic Systems Labora-tories () . - (), . - - - . , - - (/) . 5-30 / . (), (), - - . Diagnostic Systems Laboratories () . 1 (HSV-1), (CmV), ( . neumoniae), (H) - (-) .

, - () 100% . - loka 5000 - - () . - [23] .

- [8, 1] . , ( , , ) . p

61 2/2011

, - . , , . . - CmV HSV-1 - r=-0,69, r=-0,57 , (p

62 2/2011

CRP (r=0,37, p=0,03), C . pneumo-niae TNF (r=0,50, p=0,03) IL-1 (r=0,67, p=0,02) . C . pneumoniae CmV CRP (r=0,39 r=47 , p=0,04-0,03) . CRP, (r=0,31-0,38, p=0,04), IL-8 (r=0,39-0,52, p=0,04) TNF (r=0,60, p=0,03) . , .

. 2-4 5,10,08 5,40,3 /, - 3,80,1 / (p=0,02-0,001) . - 1,460,14 3,80,5 / (p=0,03-0,001) . - 1,800,16 / 1,20,1 / (p=0,03-0,01) . 1,130,09 / 2,030,1 / 4- (p=0,02-0,01) . - . r=-0,49 (p

63 2/2011

5 . . . . .:, 2006 . 261 . .

6 . . ., . . - -? // 2007 . . 13 . 3 . . 195-196 .

7 . . . . .: , 2001 . 423 . .

8 . . . . . .: , 2004 . 392 .

9 . . . : - // 1999 . 2 . . 81-85 .

10 . . . - : . - 2002 . 1 . . 5-9 .

11 . . . . : // . . 2003 . 4 . . 10-13 .

12 . . . . Chlamydia pneumoniae: - . // 2001 . . 9 . . 65-68 .

13 . . ., . . - // . 2004 . . 76 . 1 . . 78-82 .

14 . . . - // 2002 . . 1 . 1 . . 9-16 .

15 . - () . . . , . . , . . , . - . 2001611516 . .: , 2001 .

16 . . ., . ., . . . : , 2006 . 215 .

17 . . ., . ., . . - . // - 2009 . 1 . . 36-39 .

18 . Danesh J . et al . C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease // N Engl J med 2004 . V . 350 . 1387-97 .

19 . Fabricant C . G ., Fabricant J ., Litrenta m . m . et al . Virus-induced atherosclerosis //J . Exp . med ., 1978 . V . 148 . 335-340 .

20 . Fong I . W . et . al . Rabbit model for Chlamydia pneumoniae infection //J Clin microb 1997 . V . 35:1 . 48-52 .

21 . Gabay C ., kushnewr I . Acute-phase proteins and other systemic responses to inflammation . //N Engl J med . 1999 . V . 340 . 448-454 .

22 . Vanderheyden m ., kersschot F ., Paulus W . J . Pro-inflammatory cytokines and endothelium-dependent vasodilation in the forearm . Serial assessment in patients with congestive heart failure . //Eur Heart J 1998 . V . 19:5 . 747-752 .

23 . zigmonF . S ., Snaith R . P . The Hospital Anxiety and Depression scale // Acia Psychiatr scand 1983 . . 67 . . 361-370 .

64 2/2011

. ., . . 1 , .

()

, . , , .

: , , .

: . 8-926-363-22-50, e-mail: lsocolova@yandex .ru

shmyrev V. i., sokolova l. P.

FEATURES IN THE mETABOLISm OF BRAIN mILD TO mODERATE (DODEmENTNYH) COGNITIVE DISORDERS OF VARIOUS ORIGINS

The present article analyses characteristics of brain metabolism against the background of mild cognitive impairments of different genesis and compares data obtained from various high-technology survey techniques . Test results presented in the article provide better understanding of the pathology pathogenesis and make it possible to observe stages of its development as well as to evaluate efficiency of treatment .

Key words: the study, morphological changes of the brain neyrometabolizm.

. () ( . mild cognitive impair-ment, mCI) - , , - , [9] . , - () . , , , - (, , , ) . - - . - . - .

. - 114

18 65 () () . , - [7] . 4 :1 .

() - 1 [5] .

2 . () - (), - () .

3 . - () . 4 . , ,

() .

, / - ( ), - , - . - () 35 . ECAT EXACT 47 18F- 150-220 . () - () 12

65 2/2011

. - (), : - , [6] . 104 - ( 26 4 ) . 20 , . () - - NIHON kONDEN NEUROFAX EEG 2110 () . - . 16 , 10-20 . 96 .

. - . 35 , , 10 , 10 , 10 5 . 19 (54%) . - 5 (14%), 10 (29%) - 1 (3%) .

- 5 , , 1 . 1 . 10 () 7 , 1 , 2 . 104 . . 1 . - , - , () . - () [3] . - , , . , , , . - , , , [8] .

, ( 80-95%) -

. , , . - , . (, ) ( . [4]), () , .

. 1 .

- , . , - 24% (25 104) . 59% (61 )- 17% (18 .)- - . . .

- . , . , - , , - . , , ( ), (, ) . , - , ( , ) . , ( 59% - ) , , . , , , .

15

7

4

15

65

15

8

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