NK TB NK1.1+T TB-1 ~96 96

/ NK TB-1NK1.1T

1 (1) * * * *

(2) * * * *

(3) * * * *

2(1) * *

(2) * *

1defensin:/-defensin HIV 2complement 3cytokine 4lysozyme 5 oxygen free radicalNOPGLTB4PAFC-reactive protein(CRP

1phagocyte /

* 1 IINADPH reactive oxygen intermediateROI

LPS IFN- inducible nitric oxide synthaseiNOS NO ()

2

2NK * 1 ADCC 2 IFN-IL-12TNF-

T MHC HSP CD1 B-1 NK T TCR CD1

PRRPRRPRR * TollTLR

1 2 * RNAdsRNACpG DNA * N- * G-LPSG+

3 TCRBCR

PAMP TCRBCR

pathogen associated molecular patternPAMP

PAMP 1.,

* * * /*

2 PAMP 3 PAMPLPS PRR

(pattern-recognition receptorPRR) PAMP

1.PRR

15- MBLPRRMBLMBLMBLMBLMBLMASP-1MASP-2MBLMASPC2C4C2aC4bC3C3MBLMASPC1C1rC1sC1qMBL

2. PRR 1 * APC * PRR 2 PAMP 3 PRR

3. PRR1PRR MBLG+/G- * MBL

*

2PRR * * scanvenger receptor,SR

3PRR * TLR * PAMP

4. TollToll-like receptorTLR PRRToll

1 * TLRPAMP IL-1R * TLRPAMP NF-B

2TLR * PAMPTLR * TLR * TLR

15- TLRTollTLRPAMPTLR4LPSCD14MD-2.TLR2TLR1TLR6TLR3RNAdsRNA TLR5TLR9DNACpGGGGPIglcophosphoinositol; RSV:

3TLR

* TLRPAMP TLRPAMP (CK) NO

* APCTLRPAMP APC CK T

4TLR

* TLR4 LPSLBP LPSCD14 LBP LPSTLR4MD-2

15- LPSTLR4TollPRRNF-BLPSLBPCD14TLR4MD-2LBPLPSCD14LBPCD14LPSTLR-4MD-2TLR4NF-BT

* TLR2 TLR1TLR6 PAMP LPS

PRRPAMPPRR PAMP MBLMBLCRP LBPLPS LPSCD14CD14LPS LPSTLRR R G-/G+ LPS

TLR2G+PGNLTA LPSTLR4G-LPS TLR9 CpG Th1 NK

B

11 APCPRR APC

2T APCTLR PAMP B7MHC-II Th

3T TLR IL-12 Th

15- PAMP PRRTollPRRAPCMHC IIMHCTCRTLRPAMPIL-1IL-6IL-12 CD80/CD86 PRR-MHCTTTh1Th2

2 * *

3. (danger model theory) * APC APCAPC

* APC * APC T

* (1) APCPRR PAMP

2 /

* APCB7 B7/CD28 T * C3d CD21BCR B BTD-Ag

PRR PAMP T

NK IFN- MIL-12 Th0IFN- IL-4 Th0Th1

IL-4 IL-5 MIL-10 Th0Th2

B * FDCCR1CR2 Ag/Ab/C3b B