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AbortionAbortion (miscarriage)(miscarriage)AbortionAbortion (miscarriage)(miscarriage)
Dongzi Yang 杨冬梓
The Second Affiliated Hospital
Sun Yat-Sen University
DefinitionDefinitionDefinitionDefinition
The termination of pregnancy before the 28th week, when the fetus weight is less than 1000 grams.
Early abortion: <12th week of pregnancyLate abortion: 12th-28th week of pregnancy
Spontaneous abortionArtificial abortion
EtiologyEtiologyEtiologyEtiology
Genetic factors: chromosomal abnormal accounts 50 ~ 60% of the early abortions• Numeral abnormalities: polyploidy, triploidy, monosomy• Structural abnormalities: break, translocation, deletion
EtiologyEtiologyEtiologyEtiology
Extrinsic factors• Chemical: mercury, lead, cadmium,
smoking, • Physical: video display terminals,
radioactive materials, noise,
hyperthermia
EtiologyEtiologyEtiologyEtiology
Maternal factors• General diseases:
infection, heart diseases, hypertension, anemia• Reproductive organic diseases:
congenital uterine malformation, pelvic tumor, cervical incompetence
• Endocrine disorders:
LPD, hypothyroidism• Injuries
EtiologyEtiologyEtiologyEtiology
Defects in the developing placenta
Immunologic factors: paternal histo-compatibility antigen , maternal cellular immunity regular disorder, deficiency of maternal blocking antibody
PathologyPathologyPathologyPathology
The death of the embryo or rudimentary analog
Hemorrhage into the decidua basalis
Uterine contraction, dilation of the cervix
Expulsion of the products conception
PathologyPathologyPathologyPathology
Before the 8th week of the pregnancy, the abortus can be expelled completely
During the 8th-12th week of the pregnancy, retention of the tissue is common
After the 12th week of the pregnancy, the abortus may be expelled totally
Clinical subgroups Clinical subgroups of abortionof abortionClinical subgroups Clinical subgroups of abortionof abortion
Theatened miscarriage
Inevitable miscarriage
Incomplete miscarriage
Complete miscarriage
The developing processesThe developing processesof the abortionof the abortionThe developing processesThe developing processesof the abortionof the abortion
Threatened miscarriage
Normal pregnancy Inevitable miscarriage
Complete miscarriage Incomplete miscarriage
Classifications and Classifications and characteristicscharacteristicsClassifications and Classifications and characteristicscharacteristics
conceptus Vaginal abdominal Cervix os Uterine Subgroups expulsion bleeding pain dilation enlargement
Threatened no + -+ - compatible
miscarriage
Inevitable no + + + + + - compatible or miscarriage smaller
Incomplete part + + + + + - smaller
miscarriage
Complete all + - - - normal
miscarriage
Alternative Alternative classificationclassificationAlternative Alternative classificationclassification
Blighted ovum
Missed miscarriage
Live miscarriage
Classification of miscarriage
Normal pregnancyBlighted
ovum
Missedmiscarriage
Threatenedmiscarriage
Inevitablemiscarriage
Continuingpregnancy
Incompletemiscarriage
Completemiscarriage
Special subgroups:Special subgroups:
Missed MiscarriageMissed MiscarriageSpecial subgroups:Special subgroups:
Missed MiscarriageMissed Miscarriage
Expulsion of the conceptus does not occur
despite a prolonged period after embryonic
death.
Symptoms of pregnancy regress
Pregnancy test becomes negative
No fetal heart motion is detected
Uterine enlargement ceases
Special subgroups:
Recurrent miscarriageRecurrent miscarriageSpecial subgroups:
Recurrent miscarriageRecurrent miscarriage(Habitual abortion)
Three or more consecutive spontaneous losses
of pregnancy
First-trimester: LPD, hypothyroidism, chromosomal abnormalities, immunologic factors
Second-trimester: uterine malformations, cervical incompetence, myomas
Special subgroups:
Septic miscarriageSeptic miscarriageSpecial subgroups:
Septic miscarriageSeptic miscarriage
Any type of spontaneous miscarriage is
complicated by infection
Endometritis, parametritis, peritonitis
Fever, abdominal tenderness, uterine pain
Septicemia, septic shock
DiagnosisDiagnosisDiagnosisDiagnosis
History: amenorrhea, symptoms of pregnancy, vaginal bleeding……
Examination: general and pelvic
Ultrasounograph
Pregnancy test, ß-HCG
Others:
Differential diagnosisDifferential diagnosisDifferential diagnosisDifferential diagnosis
Ectopic pregnancy
Molar pregnancy
Dysfunctional uterine bleeding (DUB)
Pelvic infective diseases (PID)
Acute appendicitis
ManagementManagementManagementManagement
Threatened miscarriage:
rest, follow-up
Inevitable & incomplete miscarriage: Evacuation of the uterus,vacuum or suction curettage, oxytocin iv, antibiotics
Complete miscarriage:
no further therapy is necessary.
Management
Missed miscarriageMissed miscarriageManagement
Missed miscarriageMissed miscarriage
First- trimester:
suction curettage
The second-trimester:
D&E(dilation and evacuation)
D&C(dilation and curettage)
Induction of labor with intravaginal prostaglandin E2 or misoprostol
Management
Recurrent miscarriageRecurrent miscarriageManagement
Recurrent miscarriageRecurrent miscarriage
A workup for possible causes of recurrent pregnancy loss (RPL): anatomic, hormonal,genetic,and autoimmune factors (underlying maternal factors)
Incompetent cervix: cerclage designed to reinforce the cervix at the level of the internal os at the end of the first trimester, the suture is removed after 37 weeks’ gestation
Management
Septic miscarriageSeptic miscarriageManagement
Septic miscarriageSeptic miscarriage
Evacuation of the uterus within a few hours after antibiotics iv
High-dose, broad-spectrum coverage antibiotics, aggressive use before, during, and after removal of necrotic tissue by curettage
hysterectomy
Summary pointsSummary pointsSummary pointsSummary points
The most frequent etiology of miscarriage is a chromosomal abnormality of the conceptus and most of the abortions occur in the first-trimester.
The processes of the pathology decide the characteristics of the subgroups.
Ultrasound is helpful in diagnosis.
Problem-based learning (1)Problem-based learning (1)Problem-based learning (1)Problem-based learning (1)
A 22 year old women attends you with a 12 h history of vaginal bleeding accompanied by cramping lower abdominal pain. She has had 6 weeks amenorrhoea and tells you that she recently used a urinary pregnancy test from her local pharmacy; the test proved to be positive. She has had no previous pregnancies and was using no contraception.
Problem-based learning (2)Problem-based learning (2)Problem-based learning (2)Problem-based learning (2)
What is the differential diagnosis?
What features would you look for on examination?
What investigations, if any, are required?
Problem-based learning (3)Problem-based learning (3)Problem-based learning (3)Problem-based learning (3)
On examination you find no abnormality on abdominal palpation and in particular, no tenderness. On vaginal examination, however, you find blood clot in the vagina and products of conception are present in the cervix, which is dilated. What is the diagnosis and how would you manage the situation?
Figure them outFigure them outFigure them outFigure them out
May the miscarriage be converted in
inevitable miscarriage?
What is the common important procedure of the management in inevitable,
incomplete and missed miscarriage?
The End The End