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第五章 免疫细胞. 第一节 T 淋巴细胞. 一、 概述 二、 T 淋巴细胞的表面分子及作用 三、 T 淋巴细胞亚群和功能. 一、 概述. 来源于骨髓的淋巴样前祖细胞 , 在胸腺( Thymus )中发育成熟 ; 根据表面分子和功能分为若干个亚群 , 各亚群间相互调节 , 共同发挥其免疫学功能 ; 介导细胞免疫应答,并辅助介导 TD-Ag 诱导的体液免疫应答。. T 细胞在胸腺内的阴性选择和阳性选择. T 细胞识别抗原. 接受信号刺激. 与其他免疫细胞相互作用. 鉴别和分离 T 细胞. 二、 T 细胞的表面分子及其作用. - PowerPoint PPT Presentation
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T T T
,Thymus; , , ;TD-Ag
T
T
T
ZAP-701TCRCD3
T TCR TCR ; TTCR , , (V) (C) 1TCRT cell antigen receptor
, ITAM2CD3
ZAP-70
CD4 , 4Ig , 2MHC-; CD8 , ; Ig , MHC-I CD4CD8 TCRCD4 HIV gpl20 , CD4HIVCD4+2CD4CD8
31CD28CTLA-4CDl52 B7 CD28, 90CD4+T 50 CD8 + T ; TLCTLA-4CD4 +CD8 + T B7 CD28 ITIMT
2ICOSinducible costimulator B7T CD28ICOSB7-H2 CD28TTTT
3CD40 Th B CD40B B
4 CD2: 1LFA-2 LFA-3CD58 2 (SRBC)E- 395T50-70%NK 4T 5T
5LFA-1-1 ICAM-1-1T T
411 2T3 ACon A PHA PWM
T1L-1R IL-2R IL-4R IL-6RFasL(CD95) T T2
T (naiveT cell)(effector T cell) T(memory T cell) TCR TTCD4CD8 CD4+ TCD8+TTT reg (helper T cell, Th)(cytotoxicTcell,Tc)
1TTT1T: T2TIL-2(3)TGoCD44 GoCD45RAL-
2TT1TCD2+CD3+ CD4+CD8+SPT60%70%T
2T CD2+CD3+CD4-CD8-DNCD8+5%15%,, T
1CD4 160-65%TCRT2TCD3+CD4+CD8-CD4+T 3CD4+T13-17MHC-IITh3CD4+CD8+T TCR
2CD81) 30-35%TCRTTCR T ;2)TCD3+CD4-CD8+CD8+T 3)CD8+T8-10 MHC-I TcCTL
1CD4+TCD4+Th1CD4+Th Th0 ThThlTh2 Th3 Tr1IL-10Th1 ()T
2CD4+Th Th0 TGF- IL-4 IL-10Th3
Thl Th2
2CD8+T Fas / FasL
T
CTL
3CD4+CD25+TTrCD4+CD8+T1. 2. IL-103. APC
B B B B
B
B BBBB BCR
Mature B cellsImmature B cellsPre-B cellsPro-B cells
VHDHJHDHJH VLJLIgMIgDIgM BBB BRAG-1/2 VHDHJH DHJHVHDHJHVHDHJH VLJL VLJL++--mmm+dk or lk or lVpre-B + l5 k + lVpre-B + l5 k + l B --
B
B
1BCRBmIgMIg/IgBCR (B cell antigen receptor) : BCR B(mIg)BmIgMmIgD
mIgBCR- Ig/Ig: BCR Ig2Ig/Ig(CD79a/CD79b)
2 BBCRBCRB1CD19/CD21/CD81CD225
CD21CD19CD812 BC3dCDl9/CD21/CD8l /CD225BCRCDl9 BCRBCRB
B
CD40BThCD40LBCD80CD86B7.1B7.2: TBB TCD28TTCTLA-4 3.
B B-1 CD5+B-1 BCR, IgM Th
B-2CD5-B, , CD5B: B
B B1 B2CD5 + -B 5-10% 90%Ig Ig IgM IgG TI-Ag TD-Ag /
B 1.
ADCC,,
NKTBTCRBCRNKNK
1NK2NK3NKADCCNK
HLA-I(KIR)KARITAMNKITIMNK1NK
*
*
NK
2NKDNA
NKTcTCR-CD3+MHCI++NKTcMHCCD16,CD56+MHCI
*ADCC3ADCC
T APC: - B,MHC-IIAPC : antigen-presenting cellAPC
dendritic cellDC1
CD1aCD11cCD83MHC-IICD80CD86CD40CD54T
2 DCDC DC
DCDCDCDC
-Mf TTB BCR
MHCMHC
APC APC- MHCAPC - MHCTTT
APC LMP()TAP()
1 MHC ) (LMP) 8-13aa (TAP) /MHC I APC CD8+T
Ii*MHC-II**MHC-IICLIP(IIIi MHC II HLA-DMCLIPMHC-. 2MHC-
AgabMHC- /IiIiCLIPMHCHLA-DMMHC - 2 1 Ag
MHC I -
MHCII - CD8+ T
CD4+T::MHC - - TCR CD4/CD8 MHC-/MHC- 1
APCT + T
MHCMHC APC MHC MHC MHC MHC CD8T CD4T MHC/
-T-T; -TMHC ;MHC;-T , CDl (HSP) ; MHC -T -T -T ,